Drug interactions
Foscarnet + Neomycin
Severity: Moderate
Foscarnet and Neomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Foscarnet commonly causes renal impairment and electrolyte disturbances. Oral neomycin is poorly absorbed, but absorption and accumulation can occur with renal impairment or damaged gut mucosa, adding to nephrotoxic and ototoxic risk.
What this interaction means in plain words
Foscarnet and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Foscarnet belongs to Anti Virals; Neomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity, with reduced renal function increasing systemic neomycin exposure.
What to do
Monitor serum creatinine and electrolytes (calcium, magnesium, potassium, phosphate) regularly. Limit neomycin duration and consider alternatives in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Neomycin?
MediHelp rates the interaction as moderate. Foscarnet and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Foscarnet commonly causes renal impairment and electrolyte disturbances. Oral neomycin is poorly absorbed, but absorption and accumulation can occur with renal impairment or damaged gut mucosa, adding to nephrotoxic and ototoxic risk.
How serious is the interaction between Foscarnet and Neomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and electrolytes (calcium, magnesium, potassium, phosphate) regularly. Limit neomycin duration and consider alternatives in renal impairment.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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