Drug interactions
Foscarnet + Quizartinib
Severity: Major
Foscarnet and Quizartinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib causes dose-dependent QT prolongation and has a boxed warning for torsades de pointes. Foscarnet adds QT effects and electrolyte disturbances, which increases arrhythmia risk.
What this interaction means in plain words
Foscarnet and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Foscarnet belongs to Anti Virals; Quizartinib belongs to Oncology.
Why it happens
Additive QT prolongation with foscarnet-induced electrolyte abnormalities.
What to do
Monitor ECG more frequently and correct potassium, magnesium and calcium before and during treatment. Reduce quizartinib dose or interrupt per labeling if QTc rises markedly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Foscarnet with Quizartinib?
MediHelp rates the interaction as major. Foscarnet and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib causes dose-dependent QT prolongation and has a boxed warning for torsades de pointes. Foscarnet adds QT effects and electrolyte disturbances, which increases arrhythmia risk.
How serious is the interaction between Foscarnet and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG more frequently and correct potassium, magnesium and calcium before and during treatment. Reduce quizartinib dose or interrupt per labeling if QTc rises markedly.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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