Drug interactions
Foscarnet + Sertraline
Severity: Moderate
Foscarnet and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline has a small QT-prolonging effect, and foscarnet can add to this and disturb electrolytes. Risk is mainly relevant in patients with other proarrhythmic factors.
What this interaction means in plain words
Foscarnet and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Foscarnet belongs to Anti Virals; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation with foscarnet-induced electrolyte abnormalities.
What to do
Monitor ECG and electrolytes during foscarnet therapy and correct deficiencies; avoid additional QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Foscarnet with Sertraline?
MediHelp rates the interaction as moderate. Foscarnet and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline has a small QT-prolonging effect, and foscarnet can add to this and disturb electrolytes. Risk is mainly relevant in patients with other proarrhythmic factors.
How serious is the interaction between Foscarnet and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes during foscarnet therapy and correct deficiencies; avoid additional QT-prolonging drugs.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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