Drug interactions
Foscarnet + Voclosporin
Severity: Major
Foscarnet and Voclosporin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can damage the kidney. Using them together raises the risk of acute kidney injury and may cause lasting loss of renal function. Foscarnet-related electrolyte shifts may add further risk.
What this interaction means in plain words
Foscarnet and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Foscarnet belongs to Anti Virals; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity through different mechanisms: calcineurin-inhibitor afferent vasoconstriction and foscarnet tubular toxicity.
What to do
Avoid the combination where possible. If both are needed, monitor serum creatinine, eGFR and electrolytes closely, ensure hydration, and adjust doses to renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Foscarnet with Voclosporin?
MediHelp rates the interaction as major. Foscarnet and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can damage the kidney. Using them together raises the risk of acute kidney injury and may cause lasting loss of renal function. Foscarnet-related electrolyte shifts may add further risk.
How serious is the interaction between Foscarnet and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are needed, monitor serum creatinine, eGFR and electrolytes closely, ensure hydration, and adjust doses to renal function.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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