Drug interactions
Fosinopril + Linagliptin-metformin
Severity: Minor
Fosinopril and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. Renal function decline from ACE inhibition could also increase metformin accumulation.
What this interaction means in plain words
Fosinopril and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosinopril belongs to Cardiovascular; Linagliptin-metformin belongs to Endocrine.
Why it happens
ACE inhibition may increase insulin sensitivity, and reduced renal function may reduce metformin clearance.
What to do
Monitor blood glucose and renal function periodically, especially after starting or changing the dose of fosinopril.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Fosinopril with Linagliptin-metformin?
MediHelp rates the interaction as minor. Fosinopril and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors can improve insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. Renal function decline from ACE inhibition could also increase metformin accumulation.
How serious is the interaction between Fosinopril and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function periodically, especially after starting or changing the dose of fosinopril.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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