Drug interactions
Fosinopril + Oxaprozin
Severity: Major
Fosinopril and Oxaprozin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaprozin can weaken the antihypertensive effect of fosinopril. The combination may also reduce renal function and cause acute kidney injury, mainly in older, dehydrated or renally impaired patients.
What this interaction means in plain words
Fosinopril and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fosinopril belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins opposes ACE inhibitor effects and, with reduced angiotensin II-mediated efferent tone, lowers glomerular filtration.
What to do
Prefer a non-NSAID analgesic. If co-use is necessary, ensure adequate hydration and monitor blood pressure, serum creatinine and potassium, particularly after starting or changing doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Fosinopril with Oxaprozin?
MediHelp rates the interaction as major. Fosinopril and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxaprozin can weaken the antihypertensive effect of fosinopril. The combination may also reduce renal function and cause acute kidney injury, mainly in older, dehydrated or renally impaired patients.
How serious is the interaction between Fosinopril and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic. If co-use is necessary, ensure adequate hydration and monitor blood pressure, serum creatinine and potassium, particularly after starting or changing doses.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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