Drug interactions
Fosinopril + Thioridazine
Severity: Moderate
Fosinopril and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine has strong alpha-blocking activity and often causes orthostatic hypotension, which may be amplified by fosinopril. Hypotension and falls are a concern, especially in older patients.
What this interaction means in plain words
Fosinopril and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril belongs to Cardiovascular; Thioridazine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-1 blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms, especially at initiation and dose changes. Lower the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Fosinopril with Thioridazine?
MediHelp rates the interaction as moderate. Fosinopril and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine has strong alpha-blocking activity and often causes orthostatic hypotension, which may be amplified by fosinopril. Hypotension and falls are a concern, especially in older patients.
How serious is the interaction between Fosinopril and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially at initiation and dose changes. Lower the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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