Drug interactions
Fosinopril + Voclosporin
Severity: Major
Fosinopril and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can raise potassium and cause nephrotoxicity and reduced glomerular filtration. With an ACE inhibitor, hyperkalemia and renal function decline are more likely.
What this interaction means in plain words
Fosinopril and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fosinopril belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Calcineurin inhibition reduces renal potassium excretion and renal perfusion, and ACE inhibition further lowers aldosterone and efferent arteriolar tone.
What to do
Monitor serum potassium and eGFR regularly, especially at initiation and dose changes. Adjust or interrupt voclosporin per labeling if renal function falls or potassium rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Fosinopril with Voclosporin?
MediHelp rates the interaction as major. Fosinopril and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin, a calcineurin inhibitor, can raise potassium and cause nephrotoxicity and reduced glomerular filtration. With an ACE inhibitor, hyperkalemia and renal function decline are more likely.
How serious is the interaction between Fosinopril and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and eGFR regularly, especially at initiation and dose changes. Adjust or interrupt voclosporin per labeling if renal function falls or potassium rises.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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