Drug interactions
Fosinopril-hydrochlorothiazide + Insulin degludec
Severity: Moderate
Fosinopril-hydrochlorothiazide and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce the effectiveness of insulin, partly through hypokalemia. ACE inhibitors may conversely enhance insulin sensitivity, so glycemic control can shift in either direction.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
Thiazide-induced hypokalemia and reduced insulin secretion and sensitivity, partly opposed by ACE inhibitor effects.
What to do
Monitor blood glucose and potassium after starting or changing the diuretic and adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Insulin degludec?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and reduce the effectiveness of insulin, partly through hypokalemia. ACE inhibitors may conversely enhance insulin sensitivity, so glycemic control can shift in either direction.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium after starting or changing the diuretic and adjust the insulin dose as needed.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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