Drug interactions
Fosinopril-hydrochlorothiazide + Meloxicam
Severity: Moderate
Fosinopril-hydrochlorothiazide and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meloxicam can blunt the blood pressure control of fosinopril and hydrochlorothiazide. The combination raises the risk of acute kidney injury and hyperkalemia in elderly, dehydrated or renally impaired patients.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Meloxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and sodium excretion, opposing ACE inhibitor and diuretic actions.
What to do
Use paracetamol or another alternative where possible. If needed, use the lowest meloxicam dose, ensure hydration, and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Meloxicam?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meloxicam can blunt the blood pressure control of fosinopril and hydrochlorothiazide. The combination raises the risk of acute kidney injury and hyperkalemia in elderly, dehydrated or renally impaired patients.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use paracetamol or another alternative where possible. If needed, use the lowest meloxicam dose, ensure hydration, and monitor blood pressure, creatinine and potassium.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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