Drug interactions
Fosinopril-hydrochlorothiazide + Nateglinide
Severity: Minor
Fosinopril-hydrochlorothiazide and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can increase blood glucose and may reduce the effectiveness of nateglinide. The effect is generally small at usual low thiazide doses.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Nateglinide belongs to Endocrine.
Why it happens
Thiazide-induced impairment of glucose tolerance opposes the insulin secretagogue effect.
What to do
Monitor blood glucose after starting or adjusting the thiazide and adjust the antidiabetic regimen if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Nateglinide?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can increase blood glucose and may reduce the effectiveness of nateglinide. The effect is generally small at usual low thiazide doses.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or adjusting the thiazide and adjust the antidiabetic regimen if needed.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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