Drug interactions
Fosinopril-hydrochlorothiazide + Potassium chloride
Severity: Moderate
Fosinopril-hydrochlorothiazide and Potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosinopril reduces renal potassium loss while potassium chloride adds to potassium intake, which can cause hyperkalemia. Hydrochlorothiazide tends to lower potassium and may offset the effect, so the net result varies between patients, but renal impairment, diabetes and older age increase the risk.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Potassium chloride belongs to Gastrointestinal Tract.
Why it happens
ACE inhibitor-induced aldosterone suppression decreases potassium excretion, opposed in part by thiazide-induced kaliuresis.
What to do
Measure serum potassium and renal function before and shortly after starting, then periodically. Adjust or stop the potassium supplement according to results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fosinopril-hydrochlorothiazide and Potassium chloride, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Potassium chloride
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Potassium chloride?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosinopril reduces renal potassium loss while potassium chloride adds to potassium intake, which can cause hyperkalemia. Hydrochlorothiazide tends to lower potassium and may offset the effect, so the net result varies between patients, but renal impairment, diabetes and older age increase the risk.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum potassium and renal function before and shortly after starting, then periodically. Adjust or stop the potassium supplement according to results.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
