Drug interactions
Fosinopril-hydrochlorothiazide + Prednisolone
Severity: Moderate
Fosinopril-hydrochlorothiazide and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide and corticosteroids both promote potassium loss, so together they may cause additive hypokalemia. This is more important in patients with cardiac disease or on other drugs that prolong the QT interval.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Prednisolone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from thiazide and corticosteroid effects.
What to do
Monitor serum potassium during prolonged or high-dose steroid therapy and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Prednisolone?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide and corticosteroids both promote potassium loss, so together they may cause additive hypokalemia. This is more important in patients with cardiac disease or on other drugs that prolong the QT interval.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during prolonged or high-dose steroid therapy and replace potassium as needed.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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