Drug interactions
Fosinopril-hydrochlorothiazide + Tadalafil
Severity: Moderate
Fosinopril-hydrochlorothiazide and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil is a vasodilator and adds to the blood pressure lowering of the ACE inhibitor and thiazide. Symptomatic hypotension, dizziness or syncope can occur, particularly in volume-depleted or elderly patients.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilatory and hypotensive effects through PDE5 inhibition combined with ACE inhibition and diuresis.
What to do
Start tadalafil at the lowest dose and monitor blood pressure and orthostatic symptoms. Correct volume depletion before starting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Tadalafil?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil is a vasodilator and adds to the blood pressure lowering of the ACE inhibitor and thiazide. Symptomatic hypotension, dizziness or syncope can occur, particularly in volume-depleted or elderly patients.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start tadalafil at the lowest dose and monitor blood pressure and orthostatic symptoms. Correct volume depletion before starting.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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