Drug interactions
Fosinopril-hydrochlorothiazide + Terazosin
Severity: Moderate
Fosinopril-hydrochlorothiazide and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terazosin is an alpha-blocker that can cause marked first-dose hypotension, and the effect is amplified by an ACE inhibitor and a thiazide diuretic. Dizziness and fainting are most likely after the first dose or dose increases.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Terazosin belongs to Genitourinary.
Why it happens
Additive hypotensive effects from alpha-1 adrenergic blockade, ACE inhibition and diuresis.
What to do
Give the first terazosin dose at bedtime at a low dose and titrate slowly. Monitor standing blood pressure and consider reducing other antihypertensives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Terazosin?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terazosin is an alpha-blocker that can cause marked first-dose hypotension, and the effect is amplified by an ACE inhibitor and a thiazide diuretic. Dizziness and fainting are most likely after the first dose or dose increases.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the first terazosin dose at bedtime at a low dose and titrate slowly. Monitor standing blood pressure and consider reducing other antihypertensives.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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