Drug interactions
Fosinopril-hydrochlorothiazide + Timolol
Severity: Minor
Fosinopril-hydrochlorothiazide and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol adds to the blood pressure lowering of the combination product, which may cause hypotension or bradycardia. Beta-blockers may also slightly raise potassium while thiazides lower it, so the net effect on potassium is variable. Beta-blockers can mildly impair glucose tolerance alongside thiazides.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamic effects; beta-blockade may reduce cellular potassium uptake, opposing thiazide-induced potassium loss.
What to do
Monitor blood pressure and heart rate when starting or adjusting therapy. Check electrolytes periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Timolol?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Timolol adds to the blood pressure lowering of the combination product, which may cause hypotension or bradycardia. Beta-blockers may also slightly raise potassium while thiazides lower it, so the net effect on potassium is variable. Beta-blockers can mildly impair glucose tolerance alongside thiazides.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting therapy. Check electrolytes periodically.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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