Drug interactions
Fosinopril-hydrochlorothiazide + Tretinoin
Severity: Minor
Fosinopril-hydrochlorothiazide and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is photosensitizing and tretinoin can increase skin sensitivity to sunlight, so combined use may raise the risk of sunburn-like reactions. The effect is mainly with topical tretinoin and is generally manageable.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Tretinoin belongs to Dermatology.
Why it happens
Additive photosensitizing effects of the two drugs on the skin.
What to do
Advise sun avoidance, broad-spectrum sunscreen and protective clothing during combined use. Reduce tretinoin frequency if skin irritation or sunburn occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Tretinoin?
MediHelp rates the interaction as minor. Fosinopril-hydrochlorothiazide and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide is photosensitizing and tretinoin can increase skin sensitivity to sunlight, so combined use may raise the risk of sunburn-like reactions. The effect is mainly with topical tretinoin and is generally manageable.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise sun avoidance, broad-spectrum sunscreen and protective clothing during combined use. Reduce tretinoin frequency if skin irritation or sunburn occurs.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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