Drug interactions
Fosphenytoin + Liposomal doxorubicin
Severity: Moderate
Fosphenytoin and Liposomal doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin, the active metabolite, induces CYP3A4 and may lower doxorubicin exposure. Cytotoxic chemotherapy has also been reported to reduce phenytoin levels, possibly through reduced absorption, risking seizure breakthrough.
What this interaction means in plain words
Fosphenytoin and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosphenytoin belongs to Central Nervous System; Liposomal doxorubicin belongs to Oncology.
Why it happens
Phenytoin induces CYP3A4, and chemotherapy may alter phenytoin disposition by mechanisms that are not well established.
What to do
Monitor phenytoin concentrations and seizure control, and consider a non-inducing antiseizure drug such as levetiracetam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Fosphenytoin with Liposomal doxorubicin?
MediHelp rates the interaction as moderate. Fosphenytoin and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin, the active metabolite, induces CYP3A4 and may lower doxorubicin exposure. Cytotoxic chemotherapy has also been reported to reduce phenytoin levels, possibly through reduced absorption, risking seizure breakthrough.
How serious is the interaction between Fosphenytoin and Liposomal doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin concentrations and seizure control, and consider a non-inducing antiseizure drug such as levetiracetam.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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