Drug interactions
Fostemsavir + Glyburide-metformin
Severity: Moderate
Fostemsavir and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active metabolite of fostemsavir inhibits OATP1B1/1B3 and BCRP, which may increase glyburide exposure. This may increase the risk of hypoglycemia.
What this interaction means in plain words
Fostemsavir and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Glyburide-metformin belongs to Endocrine.
Why it happens
Inhibition of OATP1B1/1B3 hepatic uptake and BCRP efflux reduces glyburide clearance.
What to do
Monitor blood glucose when fostemsavir is started. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Glyburide-metformin?
MediHelp rates the interaction as moderate. Fostemsavir and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The active metabolite of fostemsavir inhibits OATP1B1/1B3 and BCRP, which may increase glyburide exposure. This may increase the risk of hypoglycemia.
How serious is the interaction between Fostemsavir and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fostemsavir is started. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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