Drug interactions
Fostemsavir + Hydrochlorothiazide-telmisartan
Severity: Minor
Fostemsavir and Hydrochlorothiazide-telmisartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's metabolite temsavir inhibits OATP1B1/1B3 and may increase telmisartan concentrations. This could enhance blood pressure lowering.
What this interaction means in plain words
Fostemsavir and Hydrochlorothiazide-telmisartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostemsavir belongs to Anti Virals; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of telmisartan.
What to do
Monitor blood pressure and reduce the telmisartan dose if hypotension or adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as minor. Fostemsavir and Hydrochlorothiazide-telmisartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostemsavir's metabolite temsavir inhibits OATP1B1/1B3 and may increase telmisartan concentrations. This could enhance blood pressure lowering.
How serious is the interaction between Fostemsavir and Hydrochlorothiazide-telmisartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and reduce the telmisartan dose if hypotension or adverse effects occur.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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