Drug interactions
Fostemsavir + Hydrochlorothiazide-valsartan
Severity: Minor
Fostemsavir and Hydrochlorothiazide-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's active metabolite temsavir inhibits OATP1B1 and OATP1B3, transporters involved in hepatic uptake of valsartan. Valsartan exposure may therefore rise, although the clinical effect is probably small.
What this interaction means in plain words
Fostemsavir and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostemsavir belongs to Anti Virals; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of valsartan.
What to do
Monitor blood pressure and renal function after starting fostemsavir, and lower the valsartan dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as minor. Fostemsavir and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostemsavir's active metabolite temsavir inhibits OATP1B1 and OATP1B3, transporters involved in hepatic uptake of valsartan. Valsartan exposure may therefore rise, although the clinical effect is probably small.
How serious is the interaction between Fostemsavir and Hydrochlorothiazide-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function after starting fostemsavir, and lower the valsartan dose if hypotension occurs.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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