Drug interactions
Fostemsavir + Ledipasvir-sofosbuvir
Severity: Minor
Fostemsavir and Ledipasvir-sofosbuvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's active moiety inhibits BCRP, and ledipasvir and sofosbuvir are BCRP substrates, so their exposure may increase modestly. The antivirals are generally well tolerated, so clinical impact is expected to be limited.
What this interaction means in plain words
Fostemsavir and Ledipasvir-sofosbuvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostemsavir belongs to Anti Virals; Ledipasvir-sofosbuvir belongs to Anti Virals.
Why it happens
BCRP inhibition by temsavir may raise intestinal absorption of ledipasvir and sofosbuvir.
What to do
Coadministration is generally acceptable; monitor for adverse effects of the HCV regimen without dose changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Ledipasvir-sofosbuvir?
MediHelp rates the interaction as minor. Fostemsavir and Ledipasvir-sofosbuvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostemsavir's active moiety inhibits BCRP, and ledipasvir and sofosbuvir are BCRP substrates, so their exposure may increase modestly. The antivirals are generally well tolerated, so clinical impact is expected to be limited.
How serious is the interaction between Fostemsavir and Ledipasvir-sofosbuvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Coadministration is generally acceptable; monitor for adverse effects of the HCV regimen without dose changes.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
Full monographs, dosing and an interaction checker in the MediHelp app
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