Drug interactions
Fostemsavir + Mitoxantrone
Severity: Moderate
Fostemsavir and Mitoxantrone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's active metabolite temsavir inhibits BCRP, and mitoxantrone is a BCRP substrate. Mitoxantrone exposure may increase, worsening myelosuppression and cardiotoxicity.
What this interaction means in plain words
Fostemsavir and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Mitoxantrone belongs to Central Nervous System.
Why it happens
Inhibition of BCRP-mediated efflux of mitoxantrone by temsavir.
What to do
Monitor blood counts and cardiac function, and consider dose adjustment of mitoxantrone if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitoxantrone
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Mitoxantrone?
MediHelp rates the interaction as moderate. Fostemsavir and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir's active metabolite temsavir inhibits BCRP, and mitoxantrone is a BCRP substrate. Mitoxantrone exposure may increase, worsening myelosuppression and cardiotoxicity.
How serious is the interaction between Fostemsavir and Mitoxantrone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, and consider dose adjustment of mitoxantrone if toxicity develops.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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