Drug interactions
Fostemsavir + Ofloxacin
Severity: Moderate
Fostemsavir and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin can prolong the QT interval, and fostemsavir has caused QTc prolongation at supratherapeutic doses. Together they may add to the risk of torsades de pointes in patients with other risk factors.
What this interaction means in plain words
Fostemsavir and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium. Consider an alternative antibiotic if QTc is already prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Ofloxacin?
MediHelp rates the interaction as moderate. Fostemsavir and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofloxacin can prolong the QT interval, and fostemsavir has caused QTc prolongation at supratherapeutic doses. Together they may add to the risk of torsades de pointes in patients with other risk factors.
How serious is the interaction between Fostemsavir and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium. Consider an alternative antibiotic if QTc is already prolonged.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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