Drug interactions
Fostemsavir + Pazopanib
Severity: Moderate
Fostemsavir and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's active metabolite temsavir inhibits BCRP, which may increase pazopanib exposure. Both drugs can also prolong the QT interval, with fostemsavir effects mainly seen at supratherapeutic doses.
What this interaction means in plain words
Fostemsavir and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Pazopanib belongs to Oncology.
Why it happens
BCRP inhibition raises pazopanib exposure, and additive QTc prolongation is possible pharmacodynamically.
What to do
Obtain a baseline ECG and monitor it periodically, and correct potassium and magnesium abnormalities. Monitor for pazopanib toxicity including liver enzyme elevation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Pazopanib?
MediHelp rates the interaction as moderate. Fostemsavir and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir's active metabolite temsavir inhibits BCRP, which may increase pazopanib exposure. Both drugs can also prolong the QT interval, with fostemsavir effects mainly seen at supratherapeutic doses.
How serious is the interaction between Fostemsavir and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically, and correct potassium and magnesium abnormalities. Monitor for pazopanib toxicity including liver enzyme elevation.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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