Drug interactions
Fostemsavir + Salbutamol
Severity: Moderate
Fostemsavir and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir has been associated with QTc prolongation at supratherapeutic exposures, and salbutamol can also lengthen the QT interval, particularly at high doses via hypokalemia. Combined use could raise arrhythmia risk in predisposed patients.
What this interaction means in plain words
Fostemsavir and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with salbutamol-induced hypokalemia as a possible contributor.
What to do
Use standard salbutamol doses and avoid excess dosing; monitor ECG and potassium in patients with QT risk factors or when fostemsavir exposure is increased.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Salbutamol?
MediHelp rates the interaction as moderate. Fostemsavir and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir has been associated with QTc prolongation at supratherapeutic exposures, and salbutamol can also lengthen the QT interval, particularly at high doses via hypokalemia. Combined use could raise arrhythmia risk in predisposed patients.
How serious is the interaction between Fostemsavir and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use standard salbutamol doses and avoid excess dosing; monitor ECG and potassium in patients with QT risk factors or when fostemsavir exposure is increased.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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