Drug interactions
Fostemsavir + Sunitinib
Severity: Moderate
Fostemsavir and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib prolongs the QT interval, and fostemsavir has caused QTc prolongation at supratherapeutic doses. Combined use may modestly raise arrhythmia risk, especially with other risk factors.
What this interaction means in plain words
Fostemsavir and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Sunitinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Use recommended fostemsavir doses and monitor ECG, correcting electrolyte abnormalities. Use extra caution in patients with existing QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Sunitinib?
MediHelp rates the interaction as moderate. Fostemsavir and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sunitinib prolongs the QT interval, and fostemsavir has caused QTc prolongation at supratherapeutic doses. Combined use may modestly raise arrhythmia risk, especially with other risk factors.
How serious is the interaction between Fostemsavir and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use recommended fostemsavir doses and monitor ECG, correcting electrolyte abnormalities. Use extra caution in patients with existing QT risk factors.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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