Drug interactions
Frovatriptan + Maprotiline
Severity: Moderate
Frovatriptan and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Co-administration of a triptan and a serotonergic antidepressant has been linked to rare serotonin syndrome. Maprotiline is only weakly serotonergic, so the risk is probably low.
What this interaction means in plain words
Frovatriptan and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Frovatriptan belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from triptan receptor agonism and monoamine reuptake inhibition.
What to do
Counsel the patient on symptoms of serotonin syndrome and monitor after any dose change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Maprotiline?
MediHelp rates the interaction as moderate. Frovatriptan and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Co-administration of a triptan and a serotonergic antidepressant has been linked to rare serotonin syndrome. Maprotiline is only weakly serotonergic, so the risk is probably low.
How serious is the interaction between Frovatriptan and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on symptoms of serotonin syndrome and monitor after any dose change.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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