Drug interactions
Frovatriptan + Mexiletine
Severity: Minor
Frovatriptan and Mexiletine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Frovatriptan is partly metabolized by CYP1A2, so mexiletine may modestly increase its exposure. Clinical consequences are probably limited, though triptan adverse effects could be more noticeable.
What this interaction means in plain words
Frovatriptan and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Frovatriptan belongs to Central Nervous System; Mexiletine belongs to Cardiovascular.
Why it happens
Mexiletine inhibits CYP1A2, reducing frovatriptan metabolism.
What to do
No dose adjustment is usually required; watch for triptan adverse effects such as dizziness, chest tightness or blood pressure rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Mexiletine?
MediHelp rates the interaction as minor. Frovatriptan and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Frovatriptan is partly metabolized by CYP1A2, so mexiletine may modestly increase its exposure. Clinical consequences are probably limited, though triptan adverse effects could be more noticeable.
How serious is the interaction between Frovatriptan and Mexiletine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; watch for triptan adverse effects such as dizziness, chest tightness or blood pressure rise.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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