Drug interactions
Frovatriptan + Procarbazine
Severity: Moderate
Frovatriptan and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak MAO inhibitor activity and could add to the serotonergic effects of frovatriptan, raising the risk of serotonin syndrome. Evidence is limited and the risk is mostly theoretical.
What this interaction means in plain words
Frovatriptan and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Frovatriptan belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Additive serotonergic effects from MAO inhibition and 5-HT1B/1D agonism.
What to do
Monitor for features of serotonin toxicity and blood pressure changes; use a non-serotonergic migraine treatment where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Frovatriptan with Procarbazine?
MediHelp rates the interaction as moderate. Frovatriptan and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak MAO inhibitor activity and could add to the serotonergic effects of frovatriptan, raising the risk of serotonin syndrome. Evidence is limited and the risk is mostly theoretical.
How serious is the interaction between Frovatriptan and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for features of serotonin toxicity and blood pressure changes; use a non-serotonergic migraine treatment where possible.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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