Drug interactions
Frovatriptan + Quetiapine
Severity: Moderate
Frovatriptan and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A theoretical risk of serotonin syndrome exists when serotonergic triptans are combined with antipsychotics that have serotonin receptor activity. Clinically significant reactions appear to be rare.
What this interaction means in plain words
Frovatriptan and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Frovatriptan belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects; the mechanism is largely theoretical and not well established.
What to do
Counsel patients about symptoms of serotonin syndrome such as agitation, tremor, sweating and fever, and seek review if they occur. Monitor mental status and autonomic signs when starting or adjusting either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Quetiapine?
MediHelp rates the interaction as moderate. Frovatriptan and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. A theoretical risk of serotonin syndrome exists when serotonergic triptans are combined with antipsychotics that have serotonin receptor activity. Clinically significant reactions appear to be rare.
How serious is the interaction between Frovatriptan and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about symptoms of serotonin syndrome such as agitation, tremor, sweating and fever, and seek review if they occur. Monitor mental status and autonomic signs when starting or adjusting either drug.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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