Drug interactions
Fruquintinib + Lorlatinib
Severity: Minor
Fruquintinib and Lorlatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A and may reduce fruquintinib exposure. Fruquintinib is metabolized by several pathways, so the effect is expected to be modest.
What this interaction means in plain words
Fruquintinib and Lorlatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fruquintinib belongs to Oncology; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, modestly increasing fruquintinib metabolism.
What to do
No dose change is generally required; monitor for response and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Fruquintinib
- Amobarbital + Fruquintinib Major
- Apalutamide + Fruquintinib Major
- Carbamazepine + Fruquintinib Major
- Enzalutamide + Fruquintinib Major
- Fruquintinib + Phenytoin Major
- Bosentan + Fruquintinib Moderate
Frequently asked questions
Can I take Fruquintinib with Lorlatinib?
MediHelp rates the interaction as minor. Fruquintinib and Lorlatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorlatinib induces CYP3A and may reduce fruquintinib exposure. Fruquintinib is metabolized by several pathways, so the effect is expected to be modest.
How serious is the interaction between Fruquintinib and Lorlatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; monitor for response and tolerability.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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