Drug interactions
Amobarbital + Fruquintinib
Severity: Major
Amobarbital and Fruquintinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is expected to lower fruquintinib concentrations by inducing CYP3A4. Fruquintinib exposure fell with strong inducers, which may compromise anticancer efficacy.
What this interaction means in plain words
Amobarbital and Fruquintinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Fruquintinib belongs to Oncology.
Why it happens
CYP3A4 induction by amobarbital increases fruquintinib metabolic clearance.
What to do
Avoid concomitant use of strong CYP3A4 inducers with fruquintinib and select an alternative sedative or anticonvulsant. Monitor tumor response if the combination is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Fruquintinib
- Apalutamide + Fruquintinib Major
- Carbamazepine + Fruquintinib Major
- Enzalutamide + Fruquintinib Major
- Fruquintinib + Phenytoin Major
- Bosentan + Fruquintinib Moderate
- Efavirenz + Fruquintinib Moderate
Frequently asked questions
Can I take Amobarbital with Fruquintinib?
MediHelp rates the interaction as major. Amobarbital and Fruquintinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital is expected to lower fruquintinib concentrations by inducing CYP3A4. Fruquintinib exposure fell with strong inducers, which may compromise anticancer efficacy.
How serious is the interaction between Amobarbital and Fruquintinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use of strong CYP3A4 inducers with fruquintinib and select an alternative sedative or anticonvulsant. Monitor tumor response if the combination is unavoidable.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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