Drug interactions
Bosentan + Fruquintinib
Severity: Moderate
Bosentan and Fruquintinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and may reduce fruquintinib exposure, though the effect of moderate inducers is expected to be limited. Reduced exposure could lessen antitumor efficacy.
What this interaction means in plain words
Bosentan and Fruquintinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Fruquintinib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, one of the pathways metabolizing fruquintinib.
What to do
Monitor for reduced tumor response and consider an alternative to bosentan if clinically possible. Avoid strong CYP3A4 inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Fruquintinib
- Amobarbital + Fruquintinib Major
- Apalutamide + Fruquintinib Major
- Carbamazepine + Fruquintinib Major
- Enzalutamide + Fruquintinib Major
- Fruquintinib + Phenytoin Major
- Efavirenz + Fruquintinib Moderate
Frequently asked questions
Can I take Bosentan with Fruquintinib?
MediHelp rates the interaction as moderate. Bosentan and Fruquintinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is a moderate CYP3A4 inducer and may reduce fruquintinib exposure, though the effect of moderate inducers is expected to be limited. Reduced exposure could lessen antitumor efficacy.
How serious is the interaction between Bosentan and Fruquintinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced tumor response and consider an alternative to bosentan if clinically possible. Avoid strong CYP3A4 inducers.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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