Drug interactions
Furosemide + Insulin degludec / insulin aspart
Severity: Moderate
Furosemide and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide may impair glucose tolerance, which can reduce the effectiveness of insulin in patients with diabetes. Hypokalemia from the diuretic can also reduce insulin secretion and sensitivity, so glycemic control may worsen.
What this interaction means in plain words
Furosemide and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diuretic-associated hypokalemia and reduced glucose tolerance antagonize insulin's glucose-lowering effect.
What to do
Monitor blood glucose and potassium when starting or changing furosemide, and adjust insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Furosemide and Insulin degludec / insulin aspart, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Furosemide and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide may impair glucose tolerance, which can reduce the effectiveness of insulin in patients with diabetes. Hypokalemia from the diuretic can also reduce insulin secretion and sensitivity, so glycemic control may worsen.
How serious is the interaction between Furosemide and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium when starting or changing furosemide, and adjust insulin dose as needed.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
