Drug interactions
furosemide + lansoprazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Increased risk of hypomagnesemia (and secondary hypokalemia/hypocalcemia) with PPI plus loop diuretic; may lead to arrhythmias or seizures.
Mechanism of action
PPIs reduce intestinal magnesium absorption; loop diuretics increase renal magnesium excretion, producing additive magnesium depletion.
Clinical management
Check baseline and periodic magnesium and potassium, especially with prolonged PPI therapy; replace deficiencies; consider alternative acid suppression or diuretic if recurrent low Mg.
Drug reference
References
- Lansoprazole Prescribing Information — FDA Label
- FDA Drug Safety Communication: Low magnesium levels associated with long-term PPI use — FDA
- Lansoprazole: Drug Interactions — Lexicomp
Frequently asked questions
Can I take furosemide with lansoprazole?
The interaction is rated: Moderate. Increased risk of hypomagnesemia (and secondary hypokalemia/hypocalcemia) with PPI plus loop diuretic; may lead to arrhythmias or seizures.
How serious is the interaction between furosemide and lansoprazole?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between furosemide and lansoprazole managed?
Check baseline and periodic magnesium and potassium, especially with prolonged PPI therapy; replace deficiencies; consider alternative acid suppression or diuretic if recurrent low Mg.
Why do furosemide and lansoprazole interact?
PPIs reduce intestinal magnesium absorption; loop diuretics increase renal magnesium excretion, producing additive magnesium depletion.
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