Drug interactions
Furosemide + Magnesium sulfate
Severity: Minor
Furosemide and Magnesium sulfate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide increases urinary magnesium excretion and can lower serum magnesium over time. This may reduce the effect of magnesium sulfate given for repletion, and the loss of fluid and electrolytes may matter in patients on magnesium therapy.
What this interaction means in plain words
Furosemide and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of the Na-K-2Cl cotransporter in the thick ascending limb reduces paracellular magnesium reabsorption, increasing renal loss.
What to do
Monitor serum magnesium, potassium and calcium, and adjust magnesium sulfate dosing to measured levels.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Furosemide and Magnesium sulfate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Magnesium sulfate?
MediHelp rates the interaction as minor. Furosemide and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Furosemide increases urinary magnesium excretion and can lower serum magnesium over time. This may reduce the effect of magnesium sulfate given for repletion, and the loss of fluid and electrolytes may matter in patients on magnesium therapy.
How serious is the interaction between Furosemide and Magnesium sulfate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium, potassium and calcium, and adjust magnesium sulfate dosing to measured levels.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
