Drug interactions
Furosemide + Meclofenamate
Severity: Moderate
Furosemide and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can blunt furosemide's diuretic and antihypertensive effects through sodium and water retention. The combination also increases the risk of acute kidney injury, particularly in volume-depleted patients.
What this interaction means in plain words
Furosemide and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, antagonizing the loop diuretic.
What to do
Monitor weight, blood pressure, edema and renal function, and avoid prolonged NSAID use in patients with heart failure or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Meclofenamate?
MediHelp rates the interaction as moderate. Furosemide and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamate can blunt furosemide's diuretic and antihypertensive effects through sodium and water retention. The combination also increases the risk of acute kidney injury, particularly in volume-depleted patients.
How serious is the interaction between Furosemide and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, blood pressure, edema and renal function, and avoid prolonged NSAID use in patients with heart failure or renal impairment.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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