Drug interactions
Furosemide + Methyclothiazide
Severity: Moderate
Furosemide and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a loop diuretic with a thiazide gives sequential nephron blockade, producing a strong diuretic response and marked loss of potassium, magnesium and sodium. Hypokalemia, hyponatremia, dehydration and renal impairment can result.
What this interaction means in plain words
Furosemide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sequential blockade of sodium reabsorption at the loop of Henle and distal tubule with additive electrolyte losses.
What to do
Monitor electrolytes, renal function, weight and blood pressure closely after starting, and supplement potassium or magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Methyclothiazide?
MediHelp rates the interaction as moderate. Furosemide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a loop diuretic with a thiazide gives sequential nephron blockade, producing a strong diuretic response and marked loss of potassium, magnesium and sodium. Hypokalemia, hyponatremia, dehydration and renal impairment can result.
How serious is the interaction between Furosemide and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, weight and blood pressure closely after starting, and supplement potassium or magnesium as needed.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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