Drug interactions
Furosemide + Nefazodone
Severity: Moderate
Furosemide and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide and antidepressants that affect serotonin, including nefazodone, can each cause hyponatremia. Together they may increase the risk of low serum sodium, particularly in elderly patients.
What this interaction means in plain words
Furosemide and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hyponatremia from diuretic-induced renal sodium loss and antidepressant-associated SIADH-type effects.
What to do
Check serum sodium at baseline and after starting combined therapy, especially in older adults, and reassess therapy if sodium falls or symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Nefazodone?
MediHelp rates the interaction as moderate. Furosemide and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide and antidepressants that affect serotonin, including nefazodone, can each cause hyponatremia. Together they may increase the risk of low serum sodium, particularly in elderly patients.
How serious is the interaction between Furosemide and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and after starting combined therapy, especially in older adults, and reassess therapy if sodium falls or symptoms appear.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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