Drug interactions
Furosemide + Nitroglycerin rectal
Severity: Moderate
Furosemide and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin causes venodilation and furosemide reduces circulating volume, so the combination can produce additive hypotension. Patients may experience dizziness, syncope or reduced organ perfusion.
What this interaction means in plain words
Furosemide and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotension from nitrate vasodilation and diuretic-induced volume depletion.
What to do
Monitor blood pressure and volume status, and reduce the dose of either drug if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Furosemide and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin causes venodilation and furosemide reduces circulating volume, so the combination can produce additive hypotension. Patients may experience dizziness, syncope or reduced organ perfusion.
How serious is the interaction between Furosemide and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and volume status, and reduce the dose of either drug if symptomatic hypotension occurs.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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