Drug interactions
Furosemide + Parecoxib
Severity: Moderate
Furosemide and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib (via its active metabolite valdecoxib) can blunt the diuretic and antihypertensive effect of furosemide through inhibition of renal prostaglandins. In volume-depleted or at-risk patients they may also add to the risk of acute kidney injury.
What this interaction means in plain words
Furosemide and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
COX-2 inhibition reduces renal prostaglandin synthesis, causing sodium and water retention and decreased renal perfusion, which opposes loop diuretic action.
What to do
Monitor blood pressure, fluid status, weight and serum creatinine, and ensure adequate hydration. Use the lowest effective parecoxib dose for the shortest time and consider an alternative analgesic in heart failure or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Parecoxib?
MediHelp rates the interaction as moderate. Furosemide and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib (via its active metabolite valdecoxib) can blunt the diuretic and antihypertensive effect of furosemide through inhibition of renal prostaglandins. In volume-depleted or at-risk patients they may also add to the risk of acute kidney injury.
How serious is the interaction between Furosemide and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, weight and serum creatinine, and ensure adequate hydration. Use the lowest effective parecoxib dose for the shortest time and consider an alternative analgesic in heart failure or renal impairment.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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