Drug interactions
Furosemide + Penicillin g aqueous
Severity: Minor
Furosemide and Penicillin g aqueous: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide competes with penicillin G for renal tubular secretion through organic anion transporters. Penicillin elimination may be slowed, giving somewhat higher and longer-lasting penicillin levels. The effect is usually modest.
What this interaction means in plain words
Furosemide and Penicillin g aqueous have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for organic anion transporter-mediated tubular secretion reduces penicillin renal clearance.
What to do
No routine adjustment is needed; consider the effect in patients with renal impairment or on high-dose penicillin and watch for neurotoxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Penicillin g aqueous?
MediHelp rates the interaction as minor. Furosemide and Penicillin g aqueous have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Furosemide competes with penicillin G for renal tubular secretion through organic anion transporters. Penicillin elimination may be slowed, giving somewhat higher and longer-lasting penicillin levels. The effect is usually modest.
How serious is the interaction between Furosemide and Penicillin g aqueous?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; consider the effect in patients with renal impairment or on high-dose penicillin and watch for neurotoxicity.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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