Drug interactions
Furosemide + Perindopril
Severity: Moderate
Furosemide and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding an ACE inhibitor to a loop diuretic can cause pronounced hypotension and acute renal function decline, particularly at initiation, in volume-depleted patients or in those with renal artery stenosis. The combination is useful in heart failure but needs careful initiation.
What this interaction means in plain words
Furosemide and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Perindopril belongs to Cardiovascular.
Why it happens
Diuretic-induced volume depletion combined with ACE inhibition reduces efferent arteriolar tone, producing additive hypotension and lower glomerular filtration.
What to do
Consider reducing or temporarily holding furosemide before starting perindopril, and begin with a low dose. Check blood pressure, creatinine and potassium within one to two weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Furosemide with Perindopril?
MediHelp rates the interaction as moderate. Furosemide and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding an ACE inhibitor to a loop diuretic can cause pronounced hypotension and acute renal function decline, particularly at initiation, in volume-depleted patients or in those with renal artery stenosis. The combination is useful in heart failure but needs careful initiation.
How serious is the interaction between Furosemide and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing or temporarily holding furosemide before starting perindopril, and begin with a low dose. Check blood pressure, creatinine and potassium within one to two weeks.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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