Drug interactions
Furosemide + Phenobarbital
Severity: Minor
Furosemide and Phenobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital may reduce the diuretic response to oral furosemide, as has been reported with phenytoin. The effect is inconsistent and typically small.
What this interaction means in plain words
Furosemide and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible reduction in furosemide absorption or enhanced metabolism; mechanism not firmly established.
What to do
Monitor diuretic response such as urine output, weight and edema, and raise the furosemide dose or use the intravenous route if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Phenobarbital?
MediHelp rates the interaction as minor. Furosemide and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenobarbital may reduce the diuretic response to oral furosemide, as has been reported with phenytoin. The effect is inconsistent and typically small.
How serious is the interaction between Furosemide and Phenobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diuretic response such as urine output, weight and edema, and raise the furosemide dose or use the intravenous route if the response is inadequate.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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