Drug interactions
Furosemide + Sacubitril / valsartan
Severity: Moderate
Furosemide and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide is commonly combined with sacubitril/valsartan in heart failure, but together they can cause symptomatic hypotension and reduced renal function, especially with volume depletion. Potassium effects are opposing, since the valsartan component tends to raise potassium while furosemide lowers it.
What this interaction means in plain words
Furosemide and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive and natriuretic effects, with angiotensin receptor blockade reducing renal perfusion pressure in volume-depleted patients.
What to do
Monitor blood pressure, renal function and serum potassium after initiation and dose changes. Reduce the furosemide dose if the patient becomes hypotensive or volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Furosemide and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide is commonly combined with sacubitril/valsartan in heart failure, but together they can cause symptomatic hypotension and reduced renal function, especially with volume depletion. Potassium effects are opposing, since the valsartan component tends to raise potassium while furosemide lowers it.
How serious is the interaction between Furosemide and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and serum potassium after initiation and dose changes. Reduce the furosemide dose if the patient becomes hypotensive or volume depleted.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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