Drug interactions
Furosemide + Salicylates
Severity: Moderate
Furosemide and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylsalicylic salicylates may reduce the diuretic response to furosemide and can add to renal risk in dehydrated patients. At high doses, competition for renal tubular secretion may also raise salicylate levels and toxicity risk.
What this interaction means in plain words
Furosemide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandins and competition for organic anion tubular secretion between salicylates and furosemide.
What to do
Monitor diuretic response, weight, renal function and signs of salicylate toxicity such as tinnitus. Use the lowest effective salicylate dose and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Salicylates?
MediHelp rates the interaction as moderate. Furosemide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylsalicylic salicylates may reduce the diuretic response to furosemide and can add to renal risk in dehydrated patients. At high doses, competition for renal tubular secretion may also raise salicylate levels and toxicity risk.
How serious is the interaction between Furosemide and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diuretic response, weight, renal function and signs of salicylate toxicity such as tinnitus. Use the lowest effective salicylate dose and ensure adequate hydration.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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