Drug interactions
Furosemide + Salsalate
Severity: Moderate
Furosemide and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is hydrolysed to salicylic acid and, like other NSAID-type agents, may diminish furosemide's diuretic effect and increase renal risk in volume-depleted patients. Salicylate toxicity such as tinnitus may be more likely at high doses with reduced renal clearance.
What this interaction means in plain words
Furosemide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin synthesis inhibition causing sodium retention, plus competition for renal tubular secretion of organic acids.
What to do
Monitor weight, edema, blood pressure and serum creatinine. Use the lowest effective salsalate dose and watch for salicylate toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Salsalate?
MediHelp rates the interaction as moderate. Furosemide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is hydrolysed to salicylic acid and, like other NSAID-type agents, may diminish furosemide's diuretic effect and increase renal risk in volume-depleted patients. Salicylate toxicity such as tinnitus may be more likely at high doses with reduced renal clearance.
How serious is the interaction between Furosemide and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema, blood pressure and serum creatinine. Use the lowest effective salsalate dose and watch for salicylate toxicity.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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