Drug interactions
Furosemide + Tobramycin inhaled
Severity: Moderate
Furosemide and Tobramycin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics and aminoglycosides can each be ototoxic and nephrotoxic, and volume depletion from furosemide may raise aminoglycoside concentrations. Systemic absorption from inhaled tobramycin is low, but it may be higher in renal impairment or with damaged airways.
What this interaction means in plain words
Furosemide and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive ototoxicity and nephrotoxicity, with volume depletion increasing aminoglycoside accumulation in the kidney.
What to do
Avoid concurrent use where possible. If it is necessary, monitor renal function, hearing and hydration status, and consider serum tobramycin levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Tobramycin inhaled?
MediHelp rates the interaction as moderate. Furosemide and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics and aminoglycosides can each be ototoxic and nephrotoxic, and volume depletion from furosemide may raise aminoglycoside concentrations. Systemic absorption from inhaled tobramycin is low, but it may be higher in renal impairment or with damaged airways.
How serious is the interaction between Furosemide and Tobramycin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If it is necessary, monitor renal function, hearing and hydration status, and consider serum tobramycin levels.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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