Drug interactions
Furosemide + Triclofos
Severity: Moderate
Furosemide and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is metabolized to trichloroethanol, like chloral hydrate. Chloral hydrate given with intravenous furosemide has caused sweating, flushing and blood pressure changes, thought to be due to displacement of thyroid hormone binding or a hypermetabolic state. The reaction is transient and uncommon.
What this interaction means in plain words
Furosemide and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Proposed protein-binding displacement and altered vasomotor response; the mechanism is not firmly established.
What to do
Monitor blood pressure and symptoms if used together, especially with intravenous furosemide, and consider another sedative if reactions occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Furosemide and Triclofos, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Triclofos?
MediHelp rates the interaction as moderate. Furosemide and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is metabolized to trichloroethanol, like chloral hydrate. Chloral hydrate given with intravenous furosemide has caused sweating, flushing and blood pressure changes, thought to be due to displacement of thyroid hormone binding or a hypermetabolic state. The reaction is transient and uncommon.
How serious is the interaction between Furosemide and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms if used together, especially with intravenous furosemide, and consider another sedative if reactions occur.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
